بررسی ایمونولوژیکی اکلامپسی و پره اکلامپسی (Gestosis)

ABSTRACT: Eclampsia and preeclampsia with the new name gestosis is one of the diseases which occurs during pregnancy. The cause and pathological mechanisms of gestosis have remaind unknown. The current temptation seems to presume that any disease of unknown etiology has an underlying immunologic cause so there is a great attention to gestosis as an immunologic disease. Any hypertension associated with proteinuria and oedema are identified as gestosis while many of these patients do not have true gestosis . Our investigations confirmed this view.Among 71 patients introduced with gestosis ,only 24 cases were determined to be studied . Many investigators mention that gestosis is due to first babies because the maturation of immune response and producing blocking factor protect the following fetals .Our study don't show this correlation ,only 42% of patients were in their first pregnancy and 58% of them were in second to 11th pregnancy. Our study was an attempt to evaluate the immune system of patient ,normal pregnant and normal non-pregnant women.Immunoglobulin levels (IgA, IgM),CIC (circulating immune complex )and C4 have no significant differences , there are differences in C3 component ,and the percent of T and B lymphocyte among pregnants with gestosis ,normal pregnant and non - pregnant women .Our study demonstrates that only pregnancy can be effective in making differences in some factors and has no significant correlation with gestosis.